Senior Scientist

  • Ladder Therapeutics
  • Job type: Permanent
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Location

Join us in setting up our lab in Stevenage, UK! 

In this role, you will establish our brand new lab space, establishing it, from the ground up. if you enjoy building things, this role is for you! You will develop high throughput screening platforms. and will work closely with the therapeutic area leads, running critical experiments to help progress the drug discovery programs.

The Role

In this role, you will be

  • Running key experiments pivotal to progressing our drug discovery programs

  • Responsible for setting up, devising new and improving existing high-throughput sequencing-based protocols (from library preparation to quality control)

  • Training of new lab personnel, including technicians and fellows

About Us

At Ladder Tx, we are a digitally native company operating at the intersection of machine learning, novel chemistry and RNA biology to shine light on the dark genome. We are creating an in-silico and in-vitro platform that enables the discovery of small molecule modulators of RNA.

The current toolkit for developing drugs is focused almost entirely on the protein targets. The actions of these proteins however are known to be influenced by areas of the genome that do not encode proteins, the non-coding genome, classically termed “junk DNA”, which encodes RNA; the transcriptome. 

Variation in the non-coding genome, the “dark genome” is associated with many diseases but remains inaccessible by classical drug discovery. Our mission is to engineer molecules targeting the dark genome.

We are curious, nimble, breaking new ground and growing fast. Come make an impact with us and be part of our story.

About you

  • PhD, or 5+ years of hands on bench experience directly related to the duties and responsibilities specified.

  • Experience with the CRISPR/Cas9 systems or pooled screening platforms

  • Experience In vitro synthesis (and quality control) of RNAs for high-throughput assays

  • Experience with mammalian cell culture (primary cells and cell lines) and molecular biology techniques (nucleic acid extraction & quality control, PCR/RT-PCR, protein extraction, western blotting, cloning)

  • Ability to work independently as well as in a team, in a fast-paced environment

  • Agile mindset and comfortable in a fast-paced environment

  • Excellent verbal and written communication skills with the ability to analyze/present data and write reports efficiently

  • Experience with cloning, plasmid preparation from bacteria 

Nice to have

  • Prior wet lab experience centered around RNA 

  • Experience with high throughput assay development and optimization

What we offer

  • The opportunity to make a difference. This is  a company where your work will have a direct impact on the experiments we run, and will impact the programs on track to be in clinic and impact patient outcomes. 

  • A place to explore the range of your interests. We pride ourselves in an environment that cultivates curiosity, creativity and autonomy. At Ladder Tx “the why” of things is always the most important question.

  • An environment designed to broaden your perspectives. We care deeply about inclusive working practices and diverse teams. Diversity is integral to our success, and an inclusive environment allows the team to do their best work.

  • A place to push your skills. We strongly encourage publication of our work and presentation of your work at industry leading conferences.

  • An expert team of advisors to help you develop. Our stellar SAB Includes industry leaders in Pharma, AI, and RNA Biology. You will work closely with thought leaders in the field and shape the future of RNA drug discovery. 

To apply send over a CV to jobs@laddertx.com

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