Senior Scientist

  • Gyroscope
  • Job type: Permanent
  • Closing by 30/10/2019
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Please apply with your CV and Cover Letter, highlighting your interest and relevant skills.

Location: London (Kings Cross)

We are currently seeking a highly motivated Senior Translational Scientist with strong a strong immunology background to join our Translational Research team. This position will report into the Scientific Director.

The Senior Translational Scientist will act as an expert in the development, validation, transfer, and troubleshooting of immunoassays and cell-based assays (including pharmacokinetic, immunogenicity, biomarkers and others as needed). The scientist will work with Gyroscope’s research and clinical teams to develop and oversee assays that will be used for internal developmental work or placed at Contract Research Organisations (CROs) or academic establishments. In addition, the scientist will anticipate obstacles related to methodology and will troubleshoot and resolve these obstacles. This scientist should be proactive, inquisitive and a self-starter who is eager to learn and thrives in fast paced environment.

The ideal candidate will have pharmaceutical industry experience in the development of biologics and be lab based. Ideally, this individual will have knowledge of relevant global health authority guidelines and industry practices relating to assay development and validation. Excellent communication practiced through oral, written and presentation skills is required.

The position will be primarily based in London although some travel to our facilities in Stevenage may be required.

Key Responsibilities

Develop, validate, transfer and troubleshoot immunoassays and cell-based assays internally and at contract research organisations

Provide scientific oversight to contracted immunoassays including review of validation protocols and reports.

Develop close and effective partnerships with other nonclinical and clinical pharmacology scientists, safety scientists, research scientists, clinicians and project teams to foster a collaborative work environment.

Complete projects and prepare reports appropriate for internal or external parties within agreed timelines.

Represent Translational Research within multidisciplinary project teams

Assist and/or train others when appropriate.

Evaluate new assay technologies and other applications for improved performance and efficiency of laboratory activities.

Prepare presentations and represent research internally and externally.

Maintain awareness of current developments in the field through comprehensive reading of the literature and attendance at appropriate scientific meetings.

May assist in the preparation of internal documents and Regulatory submissions, including authoring (under supervision)

Required attributes:

Working knowledge and hands on experience with a wide range of cellular and biochemical immunoassays and state-of-the-art molecular biology techniques is a must.

Expertise in immunogenicity-related and/or complement-related immunoassays is an advantage.

Experience with bioanalytical method development, validation and troubleshooting of immunochemistry and immunoassay techniques including multiplex approaches e.g. Luminex or MSD platforms.

Demonstrate scientific creativity, critical thinking, and analytical problem-solving skills, with a strong track record of research productivity as evidenced by high-quality publications.

Experience with guidelines and/or working in a GLP/GCP compliant environment.

Experience of working with biological samples obtained from clinical trials.

Experience of biomarker development.

Strong scientific skills with the ability to collaborate with project team members.

Excellent collaboration, communication and decision-making skills.

Demonstrated ability to solve complex problems to attain crucial project goals.

Qualifications:

Ph.D. in a Biological Science (e.g., Immunology, Biochemistry, Cell Biology, Bioanalytical or a related field) with relevant industry experience preferably within the biotech / pharmaceutical sector.

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