Senior Scientist

  • Achilles Therapeutics
  • Job type: Permanent
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About Achilles Therapeutics:

Achilles Therapeutics is a company focused on the development of T cell therapies targeting clonal neoantigens for the treatment of cancer. We use DNA sequencing data from each patient, together with our proprietary PELEUS™ bioinformatics platform, to identify clonal neoantigens specific to that patient and develop personalised T cell therapies. Originating from pioneering research at UCL, CRUK and the Francis Crick Institute, we are using our ground-breaking immuno-oncology approach to rapidly advance therapies, with our first product for Non-Small Cell Lung Cancer expected to enter the clinic in 2H 2019.

Role Summary:

We are seeking a committed, highly talented and creative Senior Scientist. The successful applicant will join a small team within the Process Development department primarily focused on gene editing of immune cells. The work will mainly be carried out at Achilles Therapeutics in collaboration with Prof Sergio Quezada’s team at University College London. Prof Quezada’s team has great expertise in tumour microenvironment and immune modulation and the successful applicant is expected to work at both the Achilles Therapeutics labs and Quezada labs (Stevenage and UCL respectively).

The post requires a highly motivated, hard-working and driven individual with extensive experience in immunology, immune-regulation, multi-colour flow cytometry, molecular biology and cell culture techniques. Candidates with previous experience in mouse models of cancer, PDX and cell therapies are specifically encouraged to apply for this position.

This is a unique opportunity to work with a leading team of scientists with an international reputation for excellence in immuno-oncology research and to join a company in an exciting start-up phase that has the ability to transform the clinical management of cancer.


• Develop/optimise gene editing protocols

• Contribute to design and analysis of neoantigen reactive T cells in a PDX model

• Participate in the Process Development team activities

• Effectively communicate scientific results to a technical and non-technical audience

• Generating suitable SOPs and following established SOPs

• Analysis and maintenance of data

This position requires:

• A PhD in immunology or relevant field (e.g., gene editing) and 3+ years of relevant work experience or equivalent

• Significant hands-on technical experience in flow cytometry and T cell functional assays

• Experience with gene editing techniques (e.g., CRISP/Cas9)

• Practical experience of genetic manipulation of cells (knock down and overexpression)

• Good knowledge of tumour immunology

• Excellent planning, organisational and time management skills, and attention to detail

• Authorship on high-quality papers in peer-reviewed journals

• Holding a Home office licence

In addition to the above, you are expected to have:

• Experience working with patient blood and tissue samples

• Exceptional communication skills

• Demonstrable excellence in problem solving within fixed timelines

• Flexibility and the ability to effectively manage multiple concurrent projects

In addition to the above, the following skills/experiences are desirable:

• Experience with humanised mice and PDX models

• High-dimensional flow cytometry data analysis

This is a two year fixed term position, based in Stevenage and London, with a competitive salary and benefits package.

Please send your CV with a covering letter by clicking Apply.

Apply now

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