Metabolomics Scientist- Industrialisation

  • Cell & Gene Therapy Catapult
  • Job type: Permanent
  • Closing by 1/11/2019
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Posted: 16/10/2019 15:15

Salary: Competitive

Location: Guy's Hospital, London

Level: Industrialisation

Deadline: 01/11/2019 17:00

Hours: 37.5

Benefits: Competitive

Job Type: Permanent

Purpose of Role:

The purpose of this role is to apply in-depth technical expertise across a range of projects to support the development of a nascent metabolomics capability. Working in multidisciplinary teams, the successful candidate will play a central role in applying metabolomics and/or proteomics to accelerate the development of a range of cell and gene therapy products. They will also be an integral part of a wider team supporting the integration of Process Analytical Technologies to develop next generation manufacturing platforms.

Key Accountabilities:

Support the establishment of an LCMS platform, including library creation, to enable discovery of metabolomic and proteomics biomarkers

Development, validation/qualification of state-of-the-art mass spectrometry assays in support of mechanistic, prognostic and diagnostic analyses in variety of biological matrices

Apply expert knowledge of metabolomics datasets to characterise and optimise cell culture processes

Perform data analysis on acquired datasets and collaborate with statisticians and data scientists to deliver results

Contribute to validation/qualification protocols and reports and present results to internal and external collaborators

Adhere to established Standard Operating Procedures, industry practice and regulatory guidance as appropriate

Maintain accurate records and manage data in line with company policies

Demonstrate competency in troubleshooting, optimisation and implementation of challenging and innovative LC-MS assays

Experience:

Strong background in analytical biochemistry/chemistry with emphasis on mass spectrometry applications in metabolomics or proteomics

Significant experience in method development, troubleshooting and complex data analysis

Strong background in the analysis of omics-based datasets with the use of online databases

Proficiency with mass spectrometry software, data analysis software (Spotfire, MATLAB, R, JMP, etc.) word processing, and graphical computer programs

Experience with chromatographic separation of various analytes by LC, ion mobility and characterization and quantification by MS or MS/MS

Experience of mammalian cell culture and the use of aseptic techniques

Knowledge / Skills / Competencies:

The ability to work in a matrix-team environment to contribute expertise and influence the design and planning of laboratory work

Ability to work within a fast-paced professional environment, maintaining a high standard of work

High degree of motivation, problem solving skills and innovative thinking

Excellent oral and written communication skills including technical report writing

Ability to work quickly and accurately under limited supervision

Good IT skills including experience of using programming languages and data analysis software packages

Excellent organisational skills with a strong focus on attention to detail

Proven ability to engage constructively with colleagues at all levels across different departments to deliver objectives

A good team player easily adaptable to new challenges

Education / Qualifications:

PhD in cell biology/biochemistry/chemistry with a strong emphasis on metabolomics or proteomics; or,

MSc with 3+ years industrial experience in metabolomics or proteomics within a cell therapy or appropriate Life Science environment

Apply now

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