Antikor Biopharma is developing a unique and innovative class of Antibody Drug Conjugate (ADC) therapy called Fragment Drug Conjugates (FDCs). FDCs offer potential benefits over larger ADCs in the treatment of solid tumours due to their rapid penetration, delivery of high amounts of cytotoxic payload and fast clearance from normal tissues, resulting in better tolerability and a high therapeutic index. Antikor has developed their technology platform and are developing first oncology products in areas of high clinical unmet need.
Recent deals in the ADC area demonstrates how established this technology has become and how valuable this emerging area is. Antikor’s more advanced and focussed approach creates a major opportunity to bring differentiating products for solid cancers into clinical development.
In 2022, Antikor secured a major government grant and new investment to continue developing products for gastric cancer other solid tumours. The Company also expects to hit key milestones in 2022-3 to enable it to further expand and consolidate the team to work with pharmaceutical company partners and on further projects. Hence these are exciting and progressive times for Antikor!
- Maintain a high level of knowledge and skills in technical R&D areas related to chemical payloads, antibodies and Antibody-drug conjugates
- Communicate technical knowledge both internally and externally, with staff and collaborators at internal meetings, presentations and conferences
- Carry out laboratory R&D using Good Laboratory and Safety Practice (GLSP)
- Produce robust and accurate experimental reports, have organised electronic data management, prepare SOPs, batch reports and internal/external study reports as required.
- Demonstrate a high level of attention to detail and work to a high standard
- Attend internal and external Antikor meetings as required
- Liaise with contract research organisations and participate in multiple projects as required
- Self-motivated with the ability to work independently
- Effective cross-functional interaction with other members of the Antikor team
- Track record of showing initiative and problem-solving
- Well organised with the ability to prioritise work supporting multiple programs
- BSc/MSc in Molecular Biology/Biochemistry or related discipline
- PhD in Molecular Biology/Biochemistry/Cell Biology or related discipline
- Preferably, at least 1 years’ post-doctoral experience.
- If no PhD-you will have at least 3 years’ post-graduate experience in a biotechnology/industrial environment
Key skills (essential)
- Background in cancer research and immunology research
- Strong hands-on experience in cell biology
- Fluent in aseptic technique
- Expertise in culture of mammalian cells and primary cells, particularly PBMC derived T cells
- Cell assay techniques, including cytotoxicity and proliferation assays, cytokine detection assays, apoptosis assays, etc.
- Experience in immunological techniques including ELISA, SDS-PAGE, western blot, FACS, immunofluorescence microscopy, immunohistochemistry
- Lab-based experience in or immuno-oncology
- Development and execution of cell-based assays to support early candidate evaluation and subsequent selection
- Identification and development of new assays and analytical techniques as appropriate to answer research questions or to optimise current protocols
- Expertise in analysis of in vivo pharmacokinetics (rodents)
- Purification of antibodies from hybridoma cells lines and quality control
- Experience with protein analysis techniques using protein-protein interaction analysis (BIAcore™)
- Ability to carry out micro-scale synthetic organic chemistry
- Competitive salary, including bonuses
- Flexible working
- HMRC-approved Share options scheme
- Pension scheme
- Private healthcare
- Access to the GSK subsidised restaurant, shop, sports centre, shuttle bus to/from Stevenage station.
Send CVs/covering email to firstname.lastname@example.org