Assay Development Scientist (Biology)
LifeArc is a self-funded medical research charity. Our mission is to advance translation of early science into health care treatments or diagnostics that can be taken through to full development and made available to patients. We have been doing this for more than 25 years and our work has resulted in four licensed medicines and a diagnostic for antibiotic resistance.
Our success allows us to explore new approaches to stimulate and fund translation. We have our own drug discovery and diagnostics development facilities, supported by experts in technology transfer and intellectual property who also provide services to other organisations. Our model is built on collaboration, and we partner with a broad range of groups including medical research charities, research organisations, industry, and academic scientists. We are motivated by patient need and scientific opportunity.
This role provides industry-standard assays to enable prosecution of drug discovery programs at LifeArc. The role is lab-based and encompasses reagent generation, assay design, and validation, through to assay automation, hit identification, and hit-to-lead. In addition, the role holder supports established drug discovery projects to provide mechanistic assays for hit validation and lead generation.
Who you are
Post-Doctoral or graduate Scientist with several years’ assay development experience gained in an industrial setting. Bench scientist with experience in developing robust assays in support of medicinal chemistry or biologics programs. You will have experience with both in vitro biochemical (e.g. enzymes) and cellular (e.g. reporter assay) development and various assay technologies and read-outs suitable for support of drug development. You will have experience with hit validation methods and mechanism of action studies and be familiar with high-density plate formats and assay automation.
A basic understanding of molecular biology techniques and expression/purification of proteins in bacteria and/or mammalian cells as well as practical experience in mammalian cell culture is essential.
Your salary will be determined by qualifications and experience. In addition, LifeArc offers a defined contribution pension scheme, private health insurance, a flexible benefits scheme, and 31 days paid holiday per year.
LifeArc is committed to the principles and practices of equal opportunities and to encouraging the establishment of a diverse workforce. It is our policy to employ individuals based on their suitability for the work to be performed and their potential for development, regardless of age, sex, race, colour, nationality, ethnic or national origin, disability, marital status, pregnancy or maternity, sexual orientation, gender reassignment, religion or belief. This includes creating a culture that fully reflects our commitment to equal opportunities for all.
To apply please email your CV and covering letter explaining why you want to work for LifeArc to firstname.lastname@example.org or by post to Recruitment, LifeArc, Accelerator Building, Open Innovation Campus, Stevenage, SG1 2FX (electronic applications preferred).
Closing Date – Friday 5th March 2021